Zasocitinib
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Hodoodo CAT#: H130064

CAS#: 2272904-53-5

Description: Zasocitinib, also commonly known as NDI-034858 and TAK-279, is an allosteric TYK2 inhibitor for anti-inflammatory applications. Phase 2b trials have been undergone for use of Zasocitinib as a treatment for moderate-to-severe plaque psoriasis in adults.

Chemical Structure

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Zasocitinib
CAS# 2272904-53-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H130064
Name: Zasocitinib
CAS#: 2272904-53-5
Chemical Formula: C23H24N8O3
Exact Mass: 460.20
Molecular Weight: 460.500
Elemental Analysis: C, 59.99; H, 5.25; N, 24.33; O, 10.42

Price and Availability

Size Price Availability Quantity
1mg USD 750 2 Weeks
5mg USD 1250 2 Weeks
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Synonym: Zasocitinib; NDI-034858; NDI034858; NDI 034858; TAK-279; TAK 279; TAK279;

IUPAC/Chemical Name: N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-pyrazolo[1,5-a]pyrimidine-3-carboxamide

InChi Key: BWINBHTTZLVXGT-NVXWUHKLSA-N

InChi Code: InChI=1S/C23H24N8O3/c1-24-20-12-18(27-16-6-5-11-30(23(16)33)19-7-3-4-10-25-19)29-21-14(13-26-31(20)21)22(32)28-15-8-9-17(15)34-2/h3-7,10-13,15,17,24H,8-9H2,1-2H3,(H,27,29)(H,28,32)/t15-,17-/m1/s1

SMILES Code: O=C(C1=C2N=C(NC3=CC=CN(C4=NC=CC=C4)C3=O)C=C(NC)N2N=C1)N[C@H]5[C@H](OC)CC5

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Cytokines, such as those in the interleukin (IL)-23/IL-17 axis, play an important role in the pathogenesis of psoriasis. Janus kinase, along with STAT, regulate intracellular signaling of key cytokines involved in the (IL)-23/IL-17 axis. TYK2 inhibition leads to the suppression of these signals.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 460.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Loo WJ, Turchin I, Prajapati VH, Gooderham MJ, Grewal P, Hong CH, Sauder M, Vender RB, Maari C, Papp KA. Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway. J Cutan Med Surg. 2023 Jan-Feb;27(1_suppl):3S-24S. doi: 10.1177/12034754221141680. Epub 2022 Dec 15. PMID: 36519621.

https://www.nimbustx.com/2022/11/30/nimbus-therapeutics-announces-positive-topline-results-for-phase-2b-clinical-trial-of-allosteric-tyk2-inhibitor-in-psoriasis/

https://clinicaltrials.gov/ct2/show/NCT04999839