WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122679
CAS#: N/A
Description: CDD-1431 is a potent and BMPR2-selective kinase inhibitor
Hodoodo Cat#: H122679
Name: CDD-1431
CAS#: N/A
Chemical Formula: C33H38N8O5S
Exact Mass: 658.27
Molecular Weight: 658.780
Elemental Analysis: C, 60.17; H, 5.81; N, 17.01; O, 12.14; S, 4.87
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Synonym: CDD-1431; CDD1431; CDD 1431
IUPAC/Chemical Name: N-(3-(4-(5-methoxy-2-((3-sulfamoylphenyl)amino)pyrimidin-4-yl)piperazin-1-yl)benzyl)-4-(3-(methylamino)-3-oxopropyl)benzamide
InChi Key: HSNLCCKRVCPONE-UHFFFAOYSA-N
InChi Code: InChI=1S/C33H38N8O5S/c1-35-30(42)14-11-23-9-12-25(13-10-23)32(43)36-21-24-5-3-7-27(19-24)40-15-17-41(18-16-40)31-29(46-2)22-37-33(39-31)38-26-6-4-8-28(20-26)47(34,44)45/h3-10,12-13,19-20,22H,11,14-18,21H2,1-2H3,(H,35,42)(H,36,43)(H2,34,44,45)(H,37,38,39)
SMILES Code: COC(C=N1)=C(N2CCN(C3=CC(CNC(C4=CC=C(CCC(NC)=O)C=C4)=O)=CC=C3)CC2)N=C1NC5=CC=CC(S(N)(=O)=O)=C5
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 658.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Modukuri RK, Monsivais D, Li F, Palaniappan M, Bohren KM, Tan Z, Ku AF, Wang Y, Madasu C, Li JY, Tang S, Miklossy G, Palmer SS, Young DW, Matzuk MM. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 Jan 31. doi: 10.1021/acs.jmedchem.2c01886. Epub ahead of print. PMID: 36719862.