WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130076
CAS#: N/A
Description: AG-690/11026014 is a PARP-1 inhibitor that has been shown to prevent Ang II-induced cardiomyocyte hypertrophy in mice and therefore, has potential to treat cardiac diseases.
Hodoodo Cat#: H130076
Name: AG-690/11026014
CAS#: N/A
Chemical Formula: C17H19Cl2N5O4S
Exact Mass: 459.05
Molecular Weight: 460.330
Elemental Analysis: C, 44.36; H, 4.16; Cl, 15.40; N, 15.21; O, 13.90; S, 6.96
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Synonym: AG-690/11026014; AG 690/11026014; AG690/11026014
IUPAC/Chemical Name: 2-((7-(3-(4-Chlorophenoxy)propyl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)thio)acetamide hydrochloride
InChi Key: UDICOWCXHICWSU-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H18ClN5O4S.ClH/c1-22-14-13(15(25)21-16(22)26)23(17(20-14)28-9-12(19)24)7-2-8-27-11-5-3-10(18)4-6-11;/h3-6H,2,7-9H2,1H3,(H2,19,24)(H,21,25,26);1H
SMILES Code: O=C(N)CSC(N1CCCOC2=CC=C(Cl)C=C2)=NC(N(C)C(N3)=O)=C1C3=O.[H]Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 460.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Liu M, Li Z, Chen GW, Li ZM, Wang LP, Ye JT, Luo HB, Liu PQ. AG-690/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy. Mol Cell Endocrinol. 2014 Jul 5;392(1-2):14-22. doi: 10.1016/j.mce.2014.05.010. Epub 2014 May 21. PMID: 24859603.
2. Feng GS, Zhu CG, Li ZM, Wang PX, Huang Y, Liu M, He P, Lou LL, Chen SR, Liu PQ. Synthesis of the novel PARP-1 inhibitor AG-690/11026014 and its protective effects on angiotensin II-induced mouse cardiac remodeling. Acta Pharmacol Sin. 2017 May;38(5):638-650. doi: 10.1038/aps.2016.159. Epub 2017 Feb 27. PMID: 28239158; PMCID: PMC5457692.