WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122684
CAS#: N/A
Description: Mito.IMIDZ is a mitochondria-directed antioxidant. It is not cytotoxic to SH-SY5Y and HepG2 cells up to 50 μM and after 24 h of incubation. It accumulated inside the mitochondrial matrix and acted as neuroprotective agents against iron(III), hydrogen peroxide, and tert-butyl hydroperoxide insults.
Hodoodo Cat#: H122684
Name: Mito.IMIDZ
CAS#: N/A
Chemical Formula: C24H37N3O6S
Exact Mass: 495.24
Molecular Weight: 495.640
Elemental Analysis: C, 58.16; H, 7.52; N, 8.48; O, 19.37; S, 6.47
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Mito.IMIDZ; Mito.IMIDZ; Mito.IMIDZ
IUPAC/Chemical Name: (E)-3-(10-(3-(3,4-dihydroxyphenyl)acrylamido)decyl)-1-methyl-1H-imidazol-3-ium methanesulfonate
InChi Key: HKDHNKRWPPOZFP-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H33N3O3.CH4O3S/c1-25-16-17-26(19-25)15-9-7-5-3-2-4-6-8-14-24-23(29)13-11-20-10-12-21(27)22(28)18-20;1-5(2,3)4/h10-13,16-19H,2-9,14-15H2,1H3,(H2-,24,27,28,29);1H3,(H,2,3,4)
SMILES Code: CS(=O)([O-])=O.OC1=C(O)C=CC(/C=C/C(NCCCCCCCCCC[N+]2=CN(C)C=C2)=O)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 495.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Benfeito S, Fernandes C, Chavarria D, Barreiro S, Cagide F, Sequeira L, Teixeira J, Silva R, Remião F, Oliveira PJ, Uriarte E, Borges F. Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks. J Med Chem. 2023 Jan 30. doi: 10.1021/acs.jmedchem.2c01630. Epub ahead of print. PMID: 36716281.