WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122685
CAS#: N/A
Description: PBA-1105 is a highly effective AUTOTAC molecules with promising therapeutic effects against AD
Hodoodo Cat#: H122685
Name: PBA-1105
CAS#: N/A
Chemical Formula: C39H48N2O6
Exact Mass: 640.35
Molecular Weight: 640.820
Elemental Analysis: C, 73.10; H, 7.55; N, 4.37; O, 14.98
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: PBA-1105; PBA1105; PBA 1105
IUPAC/Chemical Name: N-(1-(3,4-bis(benzyloxy)phenyl)-5,8,11-trioxa-2-azatridecan-13-yl)-4-phenylbutanamide
InChi Key: KWKXGSARCNKZPU-UHFFFAOYSA-N
InChi Code: InChI=1S/C39H48N2O6/c42-39(18-10-17-33-11-4-1-5-12-33)41-22-24-44-26-28-45-27-25-43-23-21-40-30-36-19-20-37(46-31-34-13-6-2-7-14-34)38(29-36)47-32-35-15-8-3-9-16-35/h1-9,11-16,19-20,29,40H,10,17-18,21-28,30-32H2,(H,41,42)
SMILES Code: O=C(CCCC1=CC=CC=C1)NCCOCCOCCOCCNCC2=CC(OCC3=CC=CC=C3)=C(C=C2)OCC4=CC=CC=C4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 640.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Ji, C.H., Kim, H.Y., Lee, M.J. et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun 13, 904 (2022). https://doi.org/10.1038/s41467-022-28520-4