WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130074
CAS#: N/A
Description: PQM-181 is an AChE inhibitor for the treatment of Alzheimer's disease. PQM-181 has displayed antioxidant activity against neuronal t-BOOH-induced oxidative stress, demonstrated neuroprotective ability against neurotoxicity elicited by both t-BOOH and OAβ1-42, as well as a has been shown to have a moderate ability to interfere with Aβ1-42 aggregates.
Hodoodo Cat#: H130074
Name: PQM-181
CAS#: N/A
Chemical Formula: C21H25N3O3
Exact Mass: 367.19
Molecular Weight: 367.450
Elemental Analysis: C, 68.64; H, 6.86; N, 11.44; O, 13.06
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Synonym: PQM-181; PQM 181; PQM181
IUPAC/Chemical Name: (E)-N'-(2-Hydroxybenzylidene)-4-((4-(hydroxymethyl)piperidin-1-yl)methyl)benzohydrazide
InChi Key: DRMVBMUIVSMMSH-LPYMAVHISA-N
InChi Code: InChI=1S/C21H25N3O3/c25-15-17-9-11-24(12-10-17)14-16-5-7-18(8-6-16)21(27)23-22-13-19-3-1-2-4-20(19)26/h1-8,13,17,25-26H,9-12,14-15H2,(H,23,27)/b22-13+
SMILES Code: O=C(N/N=C/C1=CC=CC=C1O)C2=CC=C(CN3CCC(CO)CC3)C=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 367.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Macedo Vaz S, de Freitas Silva M, Dos Reis Rosa Franco G, Jorge R Guimarães M, Motta R da Silva F, Gonçalves Castro N, Alvim Guedes I, Dardenne LE, Amaral Alves M, Garrett da Costa R, Beserra Pinheiro G, Germino Veras L, Renata Mortari M, Pruccoli L, Tarozzi A, Viegas C Jr. Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease. Bioorg Med Chem. 2022 Oct 1;71:116952. doi: 10.1016/j.bmc.2022.116952. Epub 2022 Aug 1. PMID: 35930852.