WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130102
CAS#: N/A
Description: LJ-4378 is an adenosine A2A/A3 receptor-ligand that has both A2AAR agonist and A3AR antagonist activity. LJ-4378 has potential to treat/prevent obesity-related metabolic diseases and moreover, was found to increase expression levels of both brown adipocyte markers, and mitochondrial proteins.
Hodoodo Cat#: H130102
Name: LJ-4378
CAS#: N/A
Chemical Formula: C15H19N5O2S
Exact Mass: 333.13
Molecular Weight: 333.410
Elemental Analysis: C, 54.04; H, 5.74; N, 21.01; O, 9.60; S, 9.62
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Synonym: LJ-4378; LJ 4378; LJ4378
IUPAC/Chemical Name: 2R,3R,4S)-2-(6-Amino-2-(hex-1-yn-1-yl)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol
InChi Key: VQABXXYIDMPKKB-DDHOLCJHSA-N
InChi Code: InChI=1S/C15H19N5O2S/c1-2-3-4-5-6-10-18-13(16)11-14(19-10)20(8-17-11)15-12(22)9(21)7-23-15/h8-9,12,15,21-22H,2-4,7H2,1H3,(H2,16,18,19)/t9-,12-,15-/m1/s1
SMILES Code: O[C@H]1[C@H](N2C=NC3=C(N)N=C(C#CCCCC)N=C23)SC[C@H]1O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 333.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Kim K, Im H, Son Y, Kim M, Tripathi SK, Jeong LS, Lee YH. Anti-obesity effects of the dual-active adenosine A2A/A3 receptor-ligand LJ-4378. Int J Obes (Lond). 2022 Dec;46(12):2128-2136. doi: 10.1038/s41366-022-01224-x. Epub 2022 Sep 27. PMID: 36167764; PMCID: PMC9678795.