WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130099
CAS#: 198701-34-7
Description: PNU-142372 is an MMP-3 inhibitor.
Hodoodo Cat#: H130099
Name: PNU-142372
CAS#: 198701-34-7
Chemical Formula: C13H10F5N5O2S2
Exact Mass: 427.02
Molecular Weight: 427.370
Elemental Analysis: C, 36.54; H, 2.36; F, 22.23; N, 16.39; O, 7.49; S, 15.00
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Synonym: PNU-142372; PNU 142372; PNU142372
IUPAC/Chemical Name: (S)-N-Methyl-3-(perfluorophenyl)-2-(3-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)ureido)propanamide
InChi Key: HZAXNPDJVFUGDS-BYPYZUCNSA-N
InChi Code: InChI=1S/C13H10F5N5O2S2/c1-19-10(24)4(20-11(25)21-12-22-23-13(26)27-12)2-3-5(14)7(16)9(18)8(17)6(3)15/h4H,2H2,1H3,(H,19,24)(H,23,26)(H2,20,21,22,25)/t4-/m0/s1
SMILES Code: O=C(NC)[C@@H](NC(NC(S1)=NNC1=S)=O)CC2=C(F)C(F)=C(F)C(F)=C2F
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 427.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Finzel BC, Baldwin ET, Bryant GL Jr, Hess GF, Wilks JW, Trepod CM, Mott JE, Marshall VP, Petzold GL, Poorman RA, O'Sullivan TJ, Schostarez HJ, Mitchell MA. Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity. Protein Sci. 1998 Oct;7(10):2118-26. doi: 10.1002/pro.5560071008. PMID: 9792098; PMCID: PMC2143846.