WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130092
CAS#: N/A
Description: RA-1 is a proteasome inhibitor with potential as a treatment for cervical cancer. It was suggested that RA-1 inhibits the proteasome due to the carbonyl group of its oxopiperidine moiety being susceptible to nucleophilic attack by the γ-hydroxythreonine side chain within the catalytic sites of the proteasome. RA-1 has also shown to promote apoptosis of cervical cancer cells containing HPV.
Hodoodo Cat#: H130092
Name: RA-1
CAS#: N/A
Chemical Formula: C29H22Cl4N2O4
Exact Mass: 602.03
Molecular Weight: 604.310
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 57.64; H, 3.67; Cl, 23.46; N, 4.64; O, 10.59
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Synonym: RA-1; RA 1; RA1
IUPAC/Chemical Name: (3,5-Bis((E)-3,4-dichlorobenzylidene)-4-oxopiperidine-1-carbonyl)-L-phenylalanine
InChi Key: HAOTXIZUGZMMSR-KJRZKRENSA-N
InChi Code: InChI=1S/C29H22Cl4N2O4/c30-22-8-6-18(12-24(22)32)10-20-15-35(16-21(27(20)36)11-19-7-9-23(31)25(33)13-19)29(39)34-26(28(37)38)14-17-4-2-1-3-5-17/h1-13,26H,14-16H2,(H,34,39)(H,37,38)/b20-10+,21-11+/t26-/m0/s1
SMILES Code: O=C(O)[C@H](CC1=CC=CC=C1)NC(N2C/C(C(/C(C2)=C/C3=CC=C(Cl)C(Cl)=C3)=O)=C\C4=CC=C(Cl)C(Cl)=C4)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 604.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Bazzaro M, Anchoori RK, Mudiam MK, Issaenko O, Kumar S, Karanam B, Lin Z, Isaksson Vogel R, Gavioli R, Destro F, Ferretti V, Roden RB, Khan SR. α,β-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells. J Med Chem. 2011 Jan 27;54(2):449-56. doi: 10.1021/jm100589p. Epub 2010 Dec 27. PMID: 21186794; PMCID: PMC3204583.