WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130088
CAS#: N/A
Description: SPAA-52 is a LMW-PTP inhibitor (Ki = 1.2 nM, >8000-fold selectivity).
Hodoodo Cat#: H130088
Name: SPAA-52
CAS#: N/A
Chemical Formula: C8H8Br2N2O4S
Exact Mass: 385.86
Molecular Weight: 388.030
Elemental Analysis: C, 24.76; H, 2.08; Br, 41.18; N, 7.22; O, 16.49; S, 8.26
This product is not in stock, which may be available by custom synthesis.
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Synonym: SPAA-52; SPAA52; SPAA 52
IUPAC/Chemical Name: ((3,5-Dibromo-4-methylphenyl)carbamoyl)sulfamic acid
InChi Key: XBWKZLBEUSPLFY-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H8Br2N2O4S/c1-4-6(9)2-5(3-7(4)10)11-8(13)12-17(14,15)16/h2-3H,1H3,(H2,11,12,13)(H,14,15,16)
SMILES Code: O=S(O)(NC(NC1=CC(Br)=C(C)C(Br)=C1)=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 388.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. He R, Wang J, Yu ZH, Moyers JS, Michael MD, Durham TB, Cramer JW, Qian Y, Lin A, Wu L, Noinaj N, Barrett DG, Zhang ZY. Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J Med Chem. 2022 Oct 27;65(20):13892-13909. doi: 10.1021/acs.jmedchem.2c01143. Epub 2022 Oct 5. PMID: 36197449.