WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130097
CAS#: N/A
Description: Synnepyrrole A is an anitbacterial agent whose mode of action has been characterized in Bacillus subtilis. Synnepyrrole A has been found to target the cytoplasmic membrane with evidence of protonophore activity occurring, and at higher concentrations, negatively has been shown to affect membrane function, allowing for normally membrane-impermeable dye molecules to pass through.
Hodoodo Cat#: H130097
Name: Synnepyrrole A
CAS#: N/A
Chemical Formula: C17H27NO4
Exact Mass: 309.19
Molecular Weight: 309.410
Elemental Analysis: C, 65.99; H, 8.80; N, 4.53; O, 20.68
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Synonym: Synnepyrrole A
IUPAC/Chemical Name: 2-(9-Methyldecyl)-1H-pyrrole-3,4-dicarboxylic acid
InChi Key: KTJTWTXWNLJBQT-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H27NO4/c1-12(2)9-7-5-3-4-6-8-10-14-15(17(21)22)13(11-18-14)16(19)20/h11-12,18H,3-10H2,1-2H3,(H,19,20)(H,21,22)
SMILES Code: O=C(C1=C(CCCCCCCCC(C)C)NC=C1C(O)=O)O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 309.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Zhang L, Esquembre LA, Xia SN, Oesterhelt F, Hughes CC, Brötz-Oesterhelt H, Teufel R. Antibacterial Synnepyrroles from Human-Associated Nocardiopsis sp. Show Protonophore Activity and Disrupt the Bacterial Cytoplasmic Membrane. ACS Chem Biol. 2022 Oct 21;17(10):2836-2848. doi: 10.1021/acschembio.2c00460. Epub 2022 Sep 30. PMID: 36179367.