DNs-HMRG

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130113

CAS#: N/A

Description: DNs-HMRG is a highly sensitive fluorescent glutathione (GSH) probe with good cell permeability, regulated by both intramolecular spirocyclization and photo-induced electron transfer. DNs-HMRG has potential for tumor detection, and due to the fact that GSH is present in higher levels in tumors, has been successfully used for detection of small tumors in mice.

Chemical Structure

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DNs-HMRG
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H130113
Name: DNs-HMRG
CAS#: N/A
Chemical Formula: C26H18N4O8S
Exact Mass: 546.08
Molecular Weight: 546.510
Elemental Analysis: C, 57.14; H, 3.32; N, 10.25; O, 23.42; S, 5.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DNs-HMRG; DNs HMRG

IUPAC/Chemical Name: N-(3'-Amino-3H-spiro[isobenzofuran-1,9'-xanthen]-6'-yl)-2,4-dinitrobenzenesulfonamide

InChi Key: SPKAMQGTNRRGEL-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H18N4O8S/c27-16-5-8-20-23(11-16)38-24-12-17(6-9-21(24)26(20)19-4-2-1-3-15(19)14-37-26)28-39(35,36)25-10-7-18(29(31)32)13-22(25)30(33)34/h1-13,28H,14,27H2

SMILES Code: O=S(C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)(NC2=CC3=C(C4(C5=C(O3)C=C(N)C=C5)OCC6=C4C=CC=C6)C=C2)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 546.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Yoshida M, Kamiya M, Yamasoba T, Urano Y. A highly sensitive, cell-membrane-permeable fluorescent probe for glutathione. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4363-4366. doi: 10.1016/j.bmcl.2014.08.033. Epub 2014 Aug 20. PMID: 25176192.

2.