PF-06455943

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130115

CAS#: 1527474-15-2

Description: PF-06455943 is a PET radioligand for imaging of the brain and LRRK2 inhibitor. Parkinson's disease is attributed to mutations in the LRRK2 gene.

Chemical Structure

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PF-06455943
CAS# 1527474-15-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H130115
Name: PF-06455943
CAS#: 1527474-15-2
Chemical Formula: C17H14FN5O
Exact Mass: 323.12
Molecular Weight: 323.330
Elemental Analysis: C, 63.15; H, 4.36; F, 5.88; N, 21.66; O, 4.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: PF-06455943; PF 06455943; PF06455943

IUPAC/Chemical Name: 2-Fluoro-3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

InChi Key: YIDVVQGSCVWPGO-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H14FN5O/c18-15-11(8-19)2-1-3-12(15)13-9-20-16-14(13)17(22-10-21-16)23-4-6-24-7-5-23/h1-3,9-10H,4-7H2,(H,20,21,22)

SMILES Code: N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1F

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 323.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Chen Z, Chen J, Chen L, Yoo CH, Rong J, Fu H, Shao T, Coffman K, Steyn SJ, Davenport AT, Daunais JB, Haider A, Collier L, Josephson L, Wey HY, Zhang L, Liang SH. Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand. J Med Chem. 2022 Oct 18. doi: 10.1021/acs.jmedchem.2c00551. Epub ahead of print. PMID: 36256881.

2. Yoo CH, Chen Z, Rani N, Chen J, Rong J, Chen L, Zhang L, Liang SH, Wey HY. Evaluation of [18F]PF-06455943 as a Potential LRRK2 PET Imaging Agent in the Brain of Nonhuman Primates. ACS Chem Neurosci. 2023 Feb 1;14(3):370-377. doi: 10.1021/acschemneuro.2c00466. Epub 2023 Jan 11. PMID: 36630128.