VU0606170

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130107

CAS#: 879054-55-4

Description: VU0606170 is a slack channels inhibitor and was shown to successfully decrease the malfunctioning spontaneous firing rate of cortical neurons, providing a potential avenue for achieving an anti-epileptic effect not previously attainable.

Chemical Structure

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VU0606170
CAS# 879054-55-4
Instruction

Theoretical Analysis

Hodoodo Cat#: H130107
Name: VU0606170
CAS#: 879054-55-4
Chemical Formula: C19H29ClN4O4S
Exact Mass: 444.16
Molecular Weight: 444.980
Elemental Analysis: C, 51.29; H, 6.57; Cl, 7.97; N, 12.59; O, 14.38; S, 7.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: VU0606170

IUPAC/Chemical Name: N-(5-Chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide

InChi Key: MESKWLXKTLBNGU-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H29ClN4O4S/c1-15-5-7-23(8-6-15)29(26,27)24-11-9-22(10-12-24)14-19(25)21-17-13-16(20)3-4-18(17)28-2/h3-4,13,15H,5-12,14H2,1-2H3,(H,21,25)

SMILES Code: O=C(NC1=CC(Cl)=CC=C1OC)CN2CCN(S(=O)(N3CCC(C)CC3)=O)CC2

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 444.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Spitznagel BD, Mishra NM, Qunies AM, Prael FJ 3rd, Du Y, Kozek KA, Lazarenko RM, Denton JS, Emmitte KA, Weaver CD. VU0606170, a Selective Slack Channels Inhibitor, Decreases Calcium Oscillations in Cultured Cortical Neurons. ACS Chem Neurosci. 2020 Nov 4;11(21):3658-3671. doi: 10.1021/acschemneuro.0c00583. Epub 2020 Oct 14. PMID: 33143429.

2. Qunies AM, Mishra NM, Spitznagel BD, Du Y, Acuña VS, David Weaver C, Emmitte KA. Structure-activity relationship studies in a new series of 2-amino-N-phenylacetamide inhibitors of Slack potassium channels. Bioorg Med Chem Lett. 2022 Nov 15;76:129013. doi: 10.1016/j.bmcl.2022.129013. Epub 2022 Sep 29. PMID: 36184030.