WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122715
CAS#: 1225291-21-3
Description: FLC26 is a CK2 inhibitor with IC50 = 9 nM
Hodoodo Cat#: H122715
Name: FLC26
CAS#: 1225291-21-3
Chemical Formula: C16H8Br2O5
Exact Mass: 437.87
Molecular Weight: 440.040
Elemental Analysis: C, 43.67; H, 1.83; Br, 36.32; O, 18.18
This product is not in stock, which may be available by custom synthesis.
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Synonym: FLC26; FLC 26; FLC-26
IUPAC/Chemical Name: 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid
InChi Key: GDOSILZXICLCEI-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H8Br2O5/c17-9-5-10-12(19)13(20)14(23-15(10)11(18)6-9)7-1-3-8(4-2-7)16(21)22/h1-6,20H,(H,21,22)
SMILES Code: OC(C(C=C1)=CC=C1C2=C(O)C(C3=CC(Br)=CC(Br)=C3O2)=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 440.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Guerra B, Bischoff N, Bdzhola VG, Yarmoluk SM, Issinger OG, Golub AG, Niefind K. A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2α Complex Structures. ACS Chem Biol. 2015 Jul 17;10(7):1654-60. doi: 10.1021/acschembio.5b00235. Epub 2015 May 15. PMID: 25961323.