WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122717
CAS#: N/A
Description: THN27 is a CK2 inhibitor.
Hodoodo Cat#: H122717
Name: THN27
CAS#: N/A
Chemical Formula: C20H19NO2
Exact Mass: 305.14
Molecular Weight: 305.380
Elemental Analysis: C, 78.66; H, 6.27; N, 4.59; O, 10.48
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Synonym: THN27; THN-27; THN 27
IUPAC/Chemical Name: 5-isopropyl-7-methyl-6-methylene-5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-dione
InChi Key: QBFUEEYKZSWUGT-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H19NO2/c1-10(2)21-18-12(4)11(3)9-15(22)16(18)17-19(21)13-7-5-6-8-14(13)20(17)23/h5-8,10-11H,4,9H2,1-3H3
SMILES Code: CC(CC1=O)C(C2=C1C3=C(N2C(C)C)C4=CC=CC=C4C3=O)=C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 305.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Lindenblatt D, Nickelsen A, Applegate VM, Hochscherf J, Witulski B, Bouaziz Z, Marminon C, Bretner M, Le Borgne M, Jose J, Niefind K. Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α' Structures. ACS Omega. 2019 Mar 19;4(3):5471-5478. doi: 10.1021/acsomega.8b03415. PMID: 31559376; PMCID: PMC6756786.