WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130119
CAS#: 945457-84-1
Description: LJ-2698 is an adenosine A3 receptor antagonist and is being explored as a treatment for Emphysema and DKD. In the murine lung model, LJ-2698 was found to minimize the negative effects of elastase-induced changes, furthermore inhibiting matrix metalloproteinase activity and cell apoptosis. Applications of LJ-2698 for the treatment of diabetic kidney disease have also been explored, with several different types of kidney injuries being successfully prevented in mice.
Hodoodo Cat#: H130119
Name: LJ-2698
CAS#: 945457-84-1
Chemical Formula: C17H16Cl2N4O2S
Exact Mass: 410.04
Molecular Weight: 411.300
Elemental Analysis: C, 49.64; H, 3.92; Cl, 17.24; N, 13.62; O, 7.78; S, 7.79
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Synonym: LJ-2698; LJ2698; LJ 2698
IUPAC/Chemical Name: (2R,3R,4S)-2-(2-Chloro-4-((3-chlorobenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrothiophene-3,4-diol
InChi Key: BZESWLKPAGCGOS-XJKCOSOUSA-N
InChi Code: InChI=1S/C17H16Cl2N4O2S/c18-10-3-1-2-9(6-10)7-20-14-11-4-5-23(15(11)22-17(19)21-14)16-13(25)12(24)8-26-16/h1-6,12-13,16,24-25H,7-8H2,(H,20,21,22)/t12-,13-,16-/m1/s1
SMILES Code: O[C@H]1[C@H](N2C=CC3=C(NCC4=CC=CC(Cl)=C4)N=C(Cl)N=C32)SC[C@H]1O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 411.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Boo HJ, Park SJ, Noh M, Min HY, Jeong LS, Lee HY. LJ-2698, an Adenosine A3 Receptor Antagonist, Alleviates Elastase-Induced Pulmonary Emphysema in Mice. Biomol Ther (Seoul). 2020 May 1;28(3):250-258. doi: 10.4062/biomolther.2019.162. PMID: 32062956; PMCID: PMC7216744.
2. Dorotea D, Cho A, Lee G, Kwon G, Lee J, Sahu PK, Jeong LS, Cha DR, Ha H. Orally active, species-independent novel A3 adenosine receptor antagonist protects against kidney injury in db/db mice. Exp Mol Med. 2018 Apr 20;50(4):1-14. doi: 10.1038/s12276-018-0053-x. PMID: 29674631; PMCID: PMC5938017.
3. Lee JY, Park JH, Kim KT, Yu J, Sahu PK, Kang N, Shin HJ, Kim MH, Kim JS, Yoon IS, Jeong LS, Kim DD. Determination and validation of LJ-2698, a potent human A3 adenosine receptor antagonist, in rat plasma by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic study. Arch Pharm Res. 2017 Aug;40(8):952-961. doi: 10.1007/s12272-017-0935-9. Epub 2017 Jul 29. PMID: 28756559.
