WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130125
CAS#: N/A
Description: SGC-PIKFYVE-1 is a PIKfyve inhibitor and functions as a cell-active chemical probe. SGC-PIKFYVE-1 has been shown to disrupt viral replication and viral entry of the β-coronavirus lifecycle. Furthermore, unlike most kinase inhibitors, SGC-PIKFYVE-1 lacks the canonical morpholine hinge-binder
Hodoodo Cat#: H130125
Name: SGC-PIKFYVE-1
CAS#: N/A
Chemical Formula: C20H21N5
Exact Mass: 331.18
Molecular Weight: 331.423
Elemental Analysis: C, 72.48; H, 6.39; N, 21.13
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Synonym: SGC-PIKFYVE-1; SGC PIKFYVE 1; SGC PIKFYVE-1; SGC-PIKFYVE1
IUPAC/Chemical Name: 11-(3-(dimethylamino)prop-1-yn-1-yl)-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine
InChi Key: DORZPJWJOBMQKC-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H21N5/c1-25(2)10-4-5-13-8-9-16-15(11-13)18-17(23-16)7-3-6-14-12-22-20(21)24-19(14)18/h8-9,11-12,23H,3,6-7,10H2,1-2H3,(H2,21,22,24)
SMILES Code: NC1=NC=C(CCC2)C(C3=C2NC4=C3C=C(C#CCN(C)C)C=C4)=N1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 331.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. https://www.thesgc.org/chemical-probes/sgc-pikfyve-1