WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130139
CAS#: N/A
Description: Anti-AD agent C10 is a dual AChE and MAO-B inhibitor (AChE: IC50 = 0.58 ± 0.05 μM; MAO-B: IC50 = 0.41 ± 0.04 μM) for the treatment of Alzheimer's disease. The compound C10 displayed binding capabilities at both the catalytic anionic site and peripheral anionic site of AChE, along with increased protection against mitochondrial dysfunction, and reduced amyloid aggregation due to AChE, suggesting that it demonstrates significant potential as a treatment for Alzheimer's disease.
Hodoodo Cat#: H130139
Name: Anti-AD agent C10
CAS#: N/A
Chemical Formula: C30H26F3NO3
Exact Mass: 505.19
Molecular Weight: 505.540
Elemental Analysis: C, 71.28; H, 5.18; F, 11.27; N, 2.77; O, 9.49
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Synonym: Anti-AD agent C10
IUPAC/Chemical Name: (E)-3-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)methylene)-7-((4-(trifluoromethyl)benzyl)oxy)chroman-4-one
InChi Key: NBRLCWFICSTVOB-LFVJCYFKSA-N
InChi Code: InChI=1S/C30H26F3NO3/c31-30(32,33)25-8-6-23(7-9-25)19-36-26-10-11-27-28(17-26)37-20-24(29(27)35)16-21-12-14-34(15-13-21)18-22-4-2-1-3-5-22/h1-12,16-17H,13-15,18-20H2/b24-16+
SMILES Code: O=C1/C(COC2=C1C=CC(OCC3=CC=C(C(F)(F)F)C=C3)=C2)=C/C4=CCN(CC5=CC=CC=C5)CC4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 505.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Li X, Li T, Zhan F, Cheng F, Lu L, Zhang B, Li J, Hu Z, Zhou S, Jia Y, Allen S, White L, Phillips J, Zhu Z, Xu J, Yao H. Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2022 Dec 7;13(23):3488-3501. doi: 10.1021/acschemneuro.2c00520. Epub 2022 Nov 16. PMID: 36383455.
