WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130143
CAS#: N/A
Description: ATTR Inhibitor M-23 is a an ATTR inhibitor for stabilization of TTR, preventing the misfolding and amyloid deposition of TTR that leads to ATTR.
Hodoodo Cat#: H130143
Name: ATTR Inhibitor M-23
CAS#: N/A
Chemical Formula: C13H8FNO6
Exact Mass: 293.03
Molecular Weight: 293.210
Elemental Analysis: C, 53.25; H, 2.75; F, 6.48; N, 4.78; O, 32.74
This product is not in stock, which may be available by custom synthesis.
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Synonym: ATTR Inhibitor M-23; ATTR Inhibitor M 23; ATTR Inhibitor M23
IUPAC/Chemical Name: (3,4-dihydroxy-5-nitrophenyl)(3-fluoro-5-hydroxyphenyl)methanone
InChi Key: UHVIBVZISWKHAF-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H8FNO6/c14-8-1-6(2-9(16)5-8)12(18)7-3-10(15(20)21)13(19)11(17)4-7/h1-5,16-17,19H
SMILES Code: O=C(C1=CC([N+]([O-])=O)=C(O)C(O)=C1)C2=CC(O)=CC(F)=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 293.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Pinheiro F, Pallarès I, Peccati F, Sánchez-Morales A, Varejão N, Bezerra F, Ortega-Alarcon D, Gonzalez D, Osorio M, Navarro S, Velázquez-Campoy A, Almeida MR, Reverter D, Busqué F, Alibés R, Sodupe M, Ventura S. Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation. J Med Chem. 2022 Nov 10;65(21):14673-14691. doi: 10.1021/acs.jmedchem.2c01195. Epub 2022 Oct 28. PMID: 36306808; PMCID: PMC9661476.