WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122751
CAS#: N/A
Description: MC0704 is a STAT3 Pathway Inhibitors for Docetaxel-Resistant Triple-Negative Breast Cancer. MC0704 effectively impeded the metastatic potential of MDA-MB-231-DTR cells in vitro, and the combination of MC0704 and docetaxel exhibited potent antitumor activities in a xenograft mouse model.
Hodoodo Cat#: H122751
Name: MC0704
CAS#: N/A
Chemical Formula: C29H21BrN4O2
Exact Mass: 536.08
Molecular Weight: 537.420
Elemental Analysis: C, 64.81; H, 3.94; Br, 14.87; N, 10.43; O, 5.95
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Synonym: MC0704; MC-0704; MC 0704
IUPAC/Chemical Name: N-(2-(1H-indol-3-yl)ethyl)-1-(4-bromobenzoyl)-9H-pyrido[3,4-b]indole-3-carboxamide
InChi Key: DLOFNWDJTXTZPF-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H21BrN4O2/c30-19-11-9-17(10-12-19)28(35)27-26-22(21-6-2-4-8-24(21)33-26)15-25(34-27)29(36)31-14-13-18-16-32-23-7-3-1-5-20(18)23/h1-12,15-16,32-33H,13-14H2,(H,31,36)
SMILES Code: O=C(C1=CC=C(Br)C=C1)C2=NC(C(NCCC3=CNC4=C3C=CC=C4)=O)=CC5=C2NC6=CC=CC=C65
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 537.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Byun WS, Lim H, Hong J, Bae ES, Lee SB, Kim Y, Lee J, Lee SK, Hong S. Design, Synthesis, and Biological Activity of Marinacarboline Analogues as STAT3 Pathway Inhibitors for Docetaxel-Resistant Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 14. doi: 10.1021/acs.jmedchem.2c01115. Epub ahead of print. PMID: 36786551.