WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130145
CAS#: N/A
Description: SZM679 is a RIPK1 inhibitor that has potential to serve as an agent for improving cognitive function in the treatment of Alzheimer's disease. SZM679 was found to reverse tumor necrosis factor-induced systemic inflammatory response syndrome, improve learning, memory dysfunction, and neuronal loss, and shows promise for the future development of novel anti-AD agents.
Hodoodo Cat#: H130145
Name: SZM679
CAS#: N/A
Chemical Formula: C27H18F5N3O5S
Exact Mass: 591.09
Molecular Weight: 591.510
Elemental Analysis: C, 54.83; H, 3.07; F, 16.06; N, 7.10; O, 13.52; S, 5.42
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Synonym: SZM679
IUPAC/Chemical Name: N-(5-fluoro-6-(4-fluoro-3-(2-(3-(trifluoromethoxy)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)-3-oxocyclobutane-1-carboxamide
InChi Key: OFQHMPFSITXRSS-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H18F5N3O5S/c28-18-5-4-16(10-20(18)33-24(37)7-13-2-1-3-17(6-13)40-27(30,31)32)39-22-12-23-21(11-19(22)29)34-26(41-23)35-25(38)14-8-15(36)9-14/h1-6,10-12,14H,7-9H2,(H,33,37)(H,34,35,38)
SMILES Code: O=C(C1CC(C1)=O)NC2=NC3=CC(F)=C(OC4=CC=C(F)C(NC(CC5=CC=CC(OC(F)(F)F)=C5)=O)=C4)C=C3S2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 591.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Sun Y, Xu L, Shao H, Quan D, Mo Z, Wang J, Zhang W, Yu J, Zhuang C, Xu K. Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer's Disease. J Med Chem. 2022 Nov 10;65(21):14957-14969. doi: 10.1021/acs.jmedchem.2c01478. Epub 2022 Oct 26. PMID: 36288088.