WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122754
CAS#: N/A
Description: Zharp-99- is a PIPK3 inhibitor. Zharp-99 is able to directly bind RIPK3 (KD = 1.35 nM) and block its kinase activity (IC50 < 1 μM by ADP-Glo) and has no impact on RIPK1 kinase activity at 10 μM.
Hodoodo Cat#: H122754
Name: Zharp-99
CAS#: N/A
Chemical Formula: C21H16ClN3O2S2
Exact Mass: 441.04
Molecular Weight: 441.950
Elemental Analysis: C, 57.07; H, 3.65; Cl, 8.02; N, 9.51; O, 7.24; S, 14.51
This product is not in stock, which may be available by custom synthesis.
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Synonym: Zharp-99; Zharp99; Zharp 99
IUPAC/Chemical Name: 8-(benzo[d]thiazol-5-ylamino)-3-cyclopropylthieno[2,3-g]quinoline 1,1-dioxide hydrochloride
InChi Key: XLZJGOZHZJNQGS-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H15N3O2S2.ClH/c25-28(26)10-16(12-1-2-12)14-8-18-15(9-21(14)28)17(5-6-22-18)24-13-3-4-20-19(7-13)23-11-27-20;/h3-12H,1-2H2,(H,22,24);1H
SMILES Code: O=S1(C=C(C2CC2)C3=C1C=C4C(N=CC=C4NC5=CC(N=CS6)=C6C=C5)=C3)=O.Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 441.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Xia K, Zhu F, Yang C, Wu S, Lin Y, Ma H, Yu X, Zhao C, Ji Y, Ge W, Wang J, Du Y, Zhang W, Yang T, Zhang X, He S. Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury. Front Cell Dev Biol. 2020 Dec 8;8:606119. doi: 10.3389/fcell.2020.606119. PMID: 33364238; PMCID: PMC7753040.