WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130162
CAS#: 1311137-58-2
Description: AUT2 is a Kv3.1 channel modulator and serves as a potential treatment of sensory hypersensitivity in those with FXS by shifting the activation of the high-threshold current to more negative potentials. This shift, in turn, reduces the high-threshold K+ current and increases the low-threshold K+ currents in neurons, restoring wave IV of the ABR. AUT2, due to its ability to modulate the excitability of neurons, can also potentially be used as treatment for hearing disorders
Hodoodo Cat#: H130162
Name: AUT2
CAS#: 1311137-58-2
Chemical Formula: C20H20N4O3
Exact Mass: 364.15
Molecular Weight: 364.410
Elemental Analysis: C, 65.92; H, 5.53; N, 15.38; O, 13.17
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Synonym: AUT2; AUT 2; AUT-2
IUPAC/Chemical Name: (R)-4-((5-(4-ethyl-2,5-dioxoimidazolidin-1-yl)pyridin-2-yl)oxy)-2-isopropylbenzonitrile
InChi Key: XIOQUVPRNWUTBF-QGZVFWFLSA-N
InChi Code: InChI=1S/C20H20N4O3/c1-4-17-19(25)24(20(26)23-17)14-6-8-18(22-11-14)27-15-7-5-13(10-21)16(9-15)12(2)3/h5-9,11-12,17H,4H2,1-3H3,(H,23,26)/t17-/m1/s1
SMILES Code: N#CC1=CC=C(OC2=NC=C(N(C(N[C@@H]3CC)=O)C3=O)C=C2)C=C1C(C)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 364.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. El-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK. Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice. J Neurosci. 2019 Jun 12;39(24):4797-4813. doi: 10.1523/JNEUROSCI.0839-18.2019. Epub 2019 Apr 1. PMID: 30936239; PMCID: PMC6561694.
2. Brown MR, El-Hassar L, Zhang Y, Alvaro G, Large CH, Kaczmarek LK. Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons. J Neurophysiol. 2016 Jul 1;116(1):106-21. doi: 10.1152/jn.00174.2016. Epub 2016 Apr 6. PMID: 27052580; PMCID: PMC4961756.