WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130153
CAS#: N/A
Description: dBET21 is a BET degrader. BET proteins, specifically alteration of the regulation of the proteins, play an important role in the development of certain types of cancers and inflammatory diseases, making BET a valuable target for treatment.
Hodoodo Cat#: H130153
Name: dBET21
CAS#: N/A
Chemical Formula: 40H42ClN7O6S
Exact Mass: 783.26
Molecular Weight: 784.330
Elemental Analysis: C, 61.25; H, 5.40; Cl, 4.52; N, 12.50; O, 12.24; S, 4.09
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Synonym: dBET21; dBET 21; dBET-21
IUPAC/Chemical Name: 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)acetamide
InChi Key: QYTHDSMOGXMOPE-XLTVJXRZSA-N
InChi Code: InChI=1S/C40H42ClN7O6S/c1-22-23(2)55-40-33(22)35(25-13-15-26(41)16-14-25)43-28(36-46-45-24(3)47(36)40)21-32(50)42-19-8-6-4-5-7-9-20-54-30-12-10-11-27-34(30)39(53)48(38(27)52)29-17-18-31(49)44-37(29)51/h10-16,28-29H,4-9,17-21H2,1-3H3,(H,42,50)(H,44,49,51)/t28-,29?/m0/s1
SMILES Code: O=C(NCCCCCCCCOC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C6=C(SC(C)=C6C)N7C(C)=NN=C47
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: BET proteins play a key role in regulating cell proliferation and cell cycle progression, by recruiting transcriptional complexes through binding to acetylated lysine residues on histones.
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 784.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Bhela IP, Ranza A, Balestrero FC, Serafini M, Aprile S, Di Martino RMC, Condorelli F, Pirali T. A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs. J Med Chem. 2022 Nov 2;65(22):15282–99. doi: 10.1021/acs.jmedchem.2c01218. Epub ahead of print. PMID: 36323630; PMCID: PMC9706574.