SHP2-targeting PROTAC SP4

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Hodoodo CAT#: H130158

CAS#: 2624181-69-5

Description: SHP2-targeting PROTAC SP4 is a PROTAC which was developed by connecting pomalidomide with SHP099, and has potential as treatment for SHP2-related diseases, such as various types of cancer. SP4 was found to significantly reduce the growth of Hela cells and promote SHP2 degradation and cell apoptosis.

Chemical Structure

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SHP2-targeting PROTAC SP4
CAS# 2624181-69-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H130158
Name: SHP2-targeting PROTAC SP4
CAS#: 2624181-69-5
Chemical Formula: C42H51Cl2N11O8
Exact Mass: 907.33
Molecular Weight: 908.840
Elemental Analysis: C, 55.51; H, 5.66; Cl, 7.80; N, 16.95; O, 14.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SHP2-targeting PROTAC SP4; SP4

IUPAC/Chemical Name: 4-((14-(4-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)-3,6,9,12-tetraoxatetradecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

InChi Key: PVZCLGQITBYVPH-UHFFFAOYSA-N

InChi Code: InChI=1S/C42H51Cl2N11O8/c1-42(10-13-53(14-11-42)33-25-47-37(38(45)49-33)29-5-2-6-30(43)36(29)44)48-24-27-26-54(52-51-27)15-17-61-19-21-63-23-22-62-20-18-60-16-12-46-31-7-3-4-28-35(31)41(59)55(40(28)58)32-8-9-34(56)50-39(32)57/h2-7,25-26,32,46,48H,8-24H2,1H3,(H2,45,49)(H,50,56,57)

SMILES Code: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCN4N=NC(CNC5(C)CCN(C6=NC(N)=C(C7=CC=CC(Cl)=C7Cl)N=C6)CC5)=C4)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 908.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Zheng M, Liu Y, Wu C, Yang K, Wang Q, Zhou Y, Chen L, Li H. Novel PROTACs for degradation of SHP2 protein. Bioorg Chem. 2021 May;110:104788. doi: 10.1016/j.bioorg.2021.104788. Epub 2021 Mar 1. PMID: 33706076.