WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130182
CAS#: 1072850-80-6
Description: AM6580 is an irreversible monoacylglycerol lipase (MGL) inhibitor.
Hodoodo Cat#: H130182
Name: AM6580
CAS#: 1072850-80-6
Chemical Formula: C23H20N6O
Exact Mass: 396.17
Molecular Weight: 396.450
Elemental Analysis: C, 69.68; H, 5.09; N, 21.20; O, 4.04
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Synonym: AM6580; AM 6580; AM-6580
IUPAC/Chemical Name: (4-(9H-fluoren-9-yl)piperazin-1-yl)(1H-[1,2,3]triazolo[4,5-b]pyridin-1-yl)methanone
InChi Key: FZFRAGWORHDDSR-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H20N6O/c30-23(29-20-10-5-11-24-22(20)25-26-29)28-14-12-27(13-15-28)21-18-8-3-1-6-16(18)17-7-2-4-9-19(17)21/h1-11,21H,12-15H2
SMILES Code: O=C(N1CCN(C2C3=C(C4=C2C=CC=C4)C=CC=C3)CC1)N5N=NC6=NC=CC=C65
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 396.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A. Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study. Biochemistry. 2013 Jul 23;52(29):5016-26. doi: 10.1021/bi400430k. Epub 2013 Jul 8. PMID: 23795559; PMCID: PMC3855488.
2. Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A. Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein Sci. 2013 Jun;22(6):774-87. doi: 10.1002/pro.2257. Epub 2013 Apr 29. PMID: 23553709; PMCID: PMC3690717.
3. Karageorgos I, Zvonok N, Janero DR, Vemuri VK, Shukla V, Wales TE, Engen JR, Makriyannis A. Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL). ACS Chem Neurosci. 2012 May 16;3(5):393-9. doi: 10.1021/cn3000263. Epub 2012 Mar 20. PMID: 22860208; PMCID: PMC3400385.