Lig4-4

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130165

CAS#: 3598-68-3

Description: Lig4-4 is a TREK-1 current inhibitor (IC50 = 2.06 μM) that has demonstrated potential for use as a protective agent against cerebral ischemia. It has been postulated that the neuroprotective effects of Lig4-4 against cerebral ischemia may be attributed to the modulation of Bcl-2 and cleaved-caspase-3 expression, leading to the inhibition of neuronal apoptosis.

Chemical Structure

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Lig4-4
CAS# 3598-68-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H130165
Name: Lig4-4
CAS#: 3598-68-3
Chemical Formula: C9H7NO4
Exact Mass: 193.04
Molecular Weight: 193.160
Elemental Analysis: C, 55.96; H, 3.65; N, 7.25; O, 33.13

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Lig4-4; Lig4 4

IUPAC/Chemical Name: 3-(nitromethyl)isobenzofuran-1(3H)-one

InChi Key: UMCCJTPPLWDHLK-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H7NO4/c11-9-7-4-2-1-3-6(7)8(14-9)5-10(12)13/h1-4,8H,5H2

SMILES Code: O=C1OC(C[N+]([O-])=O)C2=C1C=CC=C2

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 193.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Wang W, Liu D, Xiao Q, Cai J, Feng N, Xu S, Wang L, Yin D, Wang X. Lig4-4 selectively inhibits TREK-1 and plays potent neuroprotective roles in vitro and in rat MCAO model. Neurosci Lett. 2018 Apr 3;671:93-98. doi: 10.1016/j.neulet.2018.02.015. Epub 2018 Feb 10. PMID: 29438799.