WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130180
CAS#: 103926-64-3
Description: Sepimostat is an inhibitor of serine protease, displaying potential neuroprotective effects as well as shows promise as a method of treating conditions related to/ a result of ASICs disfunction.
Hodoodo Cat#: H130180
Name: Sepimostat
CAS#: 103926-64-3
Chemical Formula: C21H19N5O2
Exact Mass: 373.15
Molecular Weight: 373.420
Elemental Analysis: C, 67.55; H, 5.13; N, 18.76; O, 8.57
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Synonym: Sepimostat; 5ZFR16F4QQ
IUPAC/Chemical Name: 6-carbamimidoylnaphthalen-2-yl 4-((4,5-dihydro-1H-imidazol-2-yl)amino)benzoate
InChi Key: QMRJOIUGPCVZPH-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H19N5O2/c22-19(23)16-2-1-15-12-18(8-5-14(15)11-16)28-20(27)13-3-6-17(7-4-13)26-21-24-9-10-25-21/h1-8,11-12H,9-10H2,(H3,22,23)(H2,24,25,26)
SMILES Code: O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC4=NCCN4)C=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 373.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Zhigulin AS, Tikhonov DB, Barygin OI. Mechanisms of acid-sensing ion channels inhibition by nafamostat, sepimostat and diminazene. Eur J Pharmacol. 2023 Jan 5;938:175394. doi: 10.1016/j.ejphar.2022.175394. Epub 2022 Nov 17. PMID: 36403685.
2. Adhikari N, Banerjee S, Baidya SK, Ghosh B, Jha T. Ligand-based quantitative structural assessments of SARS-CoV-2 3CLpro inhibitors: An analysis in light of structure-based multi-molecular modeling evidences. J Mol Struct. 2022 Mar 5;1251:132041. doi: 10.1016/j.molstruc.2021.132041. Epub 2021 Nov 29. PMID: 34866654; PMCID: PMC8627846.
3. Fuwa M, Kageyama M, Ohashi K, Sasaoka M, Sato R, Tanaka M, Tashiro K. Nafamostat and sepimostat identified as novel neuroprotective agents via NR2B N-methyl-D-aspartate receptor antagonism using a rat retinal excitotoxicity model. Sci Rep. 2019 Dec 31;9(1):20409. doi: 10.1038/s41598-019-56905-x. PMID: 31892740; PMCID: PMC6938488.
