WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130173
CAS#: N/A
Description: SGRM B53, a selective glucocorticoid receptor modulator, has shown promise for use in the treatment of inflammatory and autoimmune disorders. SGRMs play a key role in dissociating the transactivation from the transrepression of the glucocorticoid receptor, with SGRM B53 being found to successfully reduce the expression of IL-6, IL-1β, and TNF-α.
Hodoodo Cat#: H130173
Name: SGRM B53
CAS#: N/A
Chemical Formula: C24H23ClN2O4S
Exact Mass: 470.11
Molecular Weight: 470.970
Elemental Analysis: C, 61.21; H, 4.92; Cl, 7.53; N, 5.95; O, 13.59; S, 6.81
This product is not in stock, which may be available by custom synthesis.
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Synonym: SGRM B53; SGRM-B53
IUPAC/Chemical Name: N-(1-benzoyl-1,2,3,4-tetrahydroquinolin-6-yl)-5-chloro-2-methoxy-4-methylbenzenesulfonamide
InChi Key: BDARZHMPJRWQLB-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H23ClN2O4S/c1-16-13-22(31-2)23(15-20(16)25)32(29,30)26-19-10-11-21-18(14-19)9-6-12-27(21)24(28)17-7-4-3-5-8-17/h3-5,7-8,10-11,13-15,26H,6,9,12H2,1-2H3
SMILES Code: O=S(C1=CC(Cl)=C(C)C=C1OC)(NC2=CC3=C(N(C(C4=CC=CC=C4)=O)CCC3)C=C2)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 470.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Li D, Bao X, Pang J, Hu X, Wang L, Wang J, Yang Z, Xu L, Wang S, Weng Q, Cui S, Hou T. Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators. J Med Chem. 2022 Dec 8;65(23):15710-15724. doi: 10.1021/acs.jmedchem.2c01082. Epub 2022 Nov 18. PMID: 36399795.