WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130174
CAS#: 946246-96-4
Description: SGRM HP-19 is a selective glucocorticoid receptor modulator (SGRM) showing promise in the treatment of inflammatory and autoimmune disorders.
Hodoodo Cat#: H130174
Name: SGRM HP-19
CAS#: 946246-96-4
Chemical Formula: C23H24N2O5S
Exact Mass: 440.14
Molecular Weight: 440.510
Elemental Analysis: C, 62.71; H, 5.49; N, 6.36; O, 18.16; S, 7.28
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Synonym: SGRM HP-19; SGRM HP19; SGRM HP 19
IUPAC/Chemical Name: N-(1-(furan-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)-2-methoxy-4,5-dimethylbenzenesulfonamide
InChi Key: NRMBLNSUKKPNMI-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H24N2O5S/c1-15-12-21(29-3)22(13-16(15)2)31(27,28)24-18-8-9-19-17(14-18)6-4-10-25(19)23(26)20-7-5-11-30-20/h5,7-9,11-14,24H,4,6,10H2,1-3H3
SMILES Code: O=S(C1=CC(C)=C(C)C=C1OC)(NC2=CC3=C(N(C(C4=CC=CO4)=O)CCC3)C=C2)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 440.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Li D, Bao X, Pang J, Hu X, Wang L, Wang J, Yang Z, Xu L, Wang S, Weng Q, Cui S, Hou T. Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators. J Med Chem. 2022 Dec 8;65(23):15710-15724. doi: 10.1021/acs.jmedchem.2c01082. Epub 2022 Nov 18. PMID: 36399795.