WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130199
CAS#: N/A
Description: ARUK2001607 is a selective PI5P4Kγ inhibitor with the ability to penetrate the brain.
Hodoodo Cat#: H130199
Name: ARUK2001607
CAS#: N/A
Chemical Formula: C14H13N3O2S2
Exact Mass: 319.04
Molecular Weight: 319.400
Elemental Analysis: C, 52.65; H, 4.10; N, 13.16; O, 10.02; S, 20.08
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Synonym: ARUK2001607; ARUK 2001607; ARUK-2001607
IUPAC/Chemical Name: 6-methyl-N-(4-(methylsulfonyl)phenyl)thieno[2,3-d]pyrimidin-4-amine
InChi Key: QVQHWPLHUNEREE-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H13N3O2S2/c1-9-7-12-13(15-8-16-14(12)20-9)17-10-3-5-11(6-4-10)21(2,18)19/h3-8H,1-2H3,(H,15,16,17)
SMILES Code: O=S(C1=CC=C(NC2=C(C=C(C)S3)C3=NC=N2)C=C1)(C)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 319.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Rooney TPC, Aldred GG, Boffey HK, Willems HMG, Edwards S, Chawner SJ, Scott DE, Green C, Winpenny D, Skidmore J, Clarke JH, Andrews SP. The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. J Med Chem. 2023 Jan 12;66(1):804-821. doi: 10.1021/acs.jmedchem.2c01693. Epub 2022 Dec 14. PMID: 36516442; PMCID: PMC9841522.