WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130208
CAS#: N/A
Description: CUMYL-CBMICA is a synthetic agonist of the cannabinoid receptor and part of an emerging class of psychoactive substances. CUMYL-CBMICA was found to have a cytotoxic effect and has been shown to be responsible for activating the CB1 receptor.
Hodoodo Cat#: H130208
Name: CUMYL-CBMICA
CAS#: N/A
Chemical Formula: C23H26N2O
Exact Mass: 346.20
Molecular Weight: 346.474
Elemental Analysis: C, 79.73; H, 7.56; N, 8.09; O, 4.62
This product is not in stock, which may be available by custom synthesis.
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Synonym: CUMYL-CBMICA; Cumyl-CBMICA; CUMYL CBMICA; SGT-280; SGT280; SGT 280
IUPAC/Chemical Name: 1-(cyclobutylmethyl)-N-(2-phenylpropan-2-yl)-1H-indole-3-carboxamide
InChi Key: INXXQNIOWMOYEJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H26N2O/c1-23(2,18-11-4-3-5-12-18)24-22(26)20-16-25(15-17-9-8-10-17)21-14-7-6-13-19(20)21/h3-7,11-14,16-17H,8-10,15H2,1-2H3,(H,24,26)
SMILES Code: O=C(C1=CN(CC2CCC2)C3=C1C=CC=C3)NC(C)(C4=CC=CC=C4)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 346.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Pulver B, Riedel J, Schönberger T, Halter S, Lucas T, Opatz T, Grafinger KE, Scheu M, Zschiesche A, Pütz M, Pützer K, Westphal F, Auwärter V. Pharmacology, prevalence in Germany, and analytical data of cyclobutylmethyl- and norbornylmethyl-type synthetic cannabinoid receptor agonists. Drug Test Anal. 2022 Dec 21. doi: 10.1002/dta.3427. Epub ahead of print. PMID: 36541839.
2. Janssens LK, Ametovski A, Sparkes E, Boyd R, Lai F, Maloney CJ, Rhook D, Gerona RR, Connolly M, Liu H, Hibbs DE, Cairns EA, Banister SD, Stove CP. Comprehensive Characterization of a Systematic Library of Alkyl and Alicyclic Synthetic Cannabinoids Related to CUMYL-PICA, CUMYL-BUTICA, CUMYL-CBMICA, and CUMYL-PINACA. ACS Chem Neurosci. 2023 Jan 4;14(1):35-52. doi: 10.1021/acschemneuro.2c00408. Epub 2022 Dec 18. PMID: 36530139.
3. Gampfer TM, Wagmann L, Pulver B, Westphal F, Flockerzi V, Meyer MR. A simplified strategy to assess the cytotoxicity of new psychoactive substances in HepG2 cells using a high content screening assay - Exemplified for nine compounds. Toxicology. 2022 Jun 30;476:153258. doi: 10.1016/j.tox.2022.153258. Epub 2022 Jul 13. PMID: 35842060.
4. Haschimi B, Grafinger KE, Pulver B, Psychou E, Halter S, Huppertz LM, Westphal F, Pütz M, Auwärter V. New synthetic cannabinoids carrying a cyclobutyl methyl side chain: Human Phase I metabolism and data on human cannabinoid receptor 1 binding and activation of Cumyl-CBMICA and Cumyl-CBMINACA. Drug Test Anal. 2021 Aug;13(8):1499-1515. doi: 10.1002/dta.3038. Epub 2021 May 5. PMID: 33788409.
5. Cannaert A, Sparkes E, Pike E, Luo JL, Fang A, Kevin RC, Ellison R, Gerona R, Banister SD, Stove CP. Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA. ACS Chem Neurosci. 2020 Dec 16;11(24):4434-4446. doi: 10.1021/acschemneuro.0c00644. Epub 2020 Nov 30. PMID: 33253529.
6. Halter S, Pulver B, Wilde M, Haschimi B, Westphal F, Riedel J, Pütz M, Schönberger T, Stoll S, Schäper J, Auwärter V. Cumyl-CBMICA: A new synthetic cannabinoid receptor agonist containing a cyclobutyl methyl side chain. Drug Test Anal. 2021 Jan;13(1):208-216. doi: 10.1002/dta.2942. Epub 2020 Oct 23. PMID: 33037749.
