WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130210
CAS#: N/A
Description: GJ2 is an irreversible inhibitor of GLS1 activity, specifically targeting the K320 residue. GJ2 treatment resulted in the reduction in the growth rate of cancer cells, trypsin digestion of KGA, and the formation of clonal tumor cells.
Hodoodo Cat#: H130210
Name: GJ2
CAS#: N/A
Chemical Formula: C27H25N7O4Se
Exact Mass: 591.11
Molecular Weight: 590.500
Elemental Analysis: C, 54.92; H, 4.27; N, 16.60; O, 10.84; Se, 13.37
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Synonym: GJ2
IUPAC/Chemical Name: (E)-3-(benzo[d][1,3]dioxol-5-yl)-N-(6-(4-(5-(2-(pyridin-2-yl)acetamido)-1,3,4-selenadiazol-2-yl)butyl)pyridazin-3-yl)acrylamide
InChi Key: IGUSAXDXFTWQKD-UKTHLTGXSA-N
InChi Code: InChI=1S/C27H25N7O4Se/c35-24(13-9-18-8-11-21-22(15-18)38-17-37-21)29-23-12-10-19(31-32-23)5-1-2-7-26-33-34-27(39-26)30-25(36)16-20-6-3-4-14-28-20/h3-4,6,8-15H,1-2,5,7,16-17H2,(H,29,32,35)(H,30,34,36)/b13-9+
SMILES Code: O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=NC=CC=C3)=O)[Se]2)C=C1)/C=C/C4=CC=C(OCO5)C5=C4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 590.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Song J, Pan C, Li J, Bai R, Zeng Z, Han Y, Chen Z, Hou W, Li Y, Ruan BH. Synthesis of Novel Kidney-Type Glutaminase Allosteric Inhibitors Targeting the Critical Lys-320 Residue. ACS Med Chem Lett. 2022 Dec 22;14(1):11-17. doi: 10.1021/acsmedchemlett.2c00302. PMID: 36655131; PMCID: PMC9841584.