WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130211
CAS#: N/A
Description: GJ5 is an irreversible inhibitor of kidney-type glutaminase (GLS1) activity, specifically targeting the K320 residue.
Hodoodo Cat#: H130211
Name: GJ5
CAS#: N/A
Chemical Formula: C27H25N7O4S
Exact Mass: 543.17
Molecular Weight: 543.600
Elemental Analysis: C, 59.66; H, 4.64; N, 18.04; O, 11.77; S, 5.90
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Synonym: GJ5
IUPAC/Chemical Name: (E)-3-(benzo[d][1,3]dioxol-5-yl)-N-(6-(4-(5-(2-(pyridin-2-yl)acetamido)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)acrylamide
InChi Key: LUWFPXNEMLWCHK-UKTHLTGXSA-N
InChi Code: InChI=1S/C27H25N7O4S/c35-24(13-9-18-8-11-21-22(15-18)38-17-37-21)29-23-12-10-19(31-32-23)5-1-2-7-26-33-34-27(39-26)30-25(36)16-20-6-3-4-14-28-20/h3-4,6,8-15H,1-2,5,7,16-17H2,(H,29,32,35)(H,30,34,36)/b13-9+
SMILES Code: O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=NC=CC=C3)=O)S2)C=C1)/C=C/C4=CC=C(OCO5)C5=C4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 543.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Song J, Pan C, Li J, Bai R, Zeng Z, Han Y, Chen Z, Hou W, Li Y, Ruan BH. Synthesis of Novel Kidney-Type Glutaminase Allosteric Inhibitors Targeting the Critical Lys-320 Residue. ACS Med Chem Lett. 2022 Dec 22;14(1):11-17. doi: 10.1021/acsmedchemlett.2c00302. PMID: 36655131; PMCID: PMC9841584.