GNF-Pf4492

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H122820

CAS#: N/A

Description: GNF-Pf4492 is a PfATP4 inhibitor.

Chemical Structure

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GNF-Pf4492
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H122820
Name: GNF-Pf4492
CAS#: N/A
Chemical Formula: C18H12BrF5N4O
Exact Mass: 474.01
Molecular Weight: 475.220
Elemental Analysis: C, 45.49; H, 2.55; Br, 16.81; F, 19.99; N, 11.79; O, 3.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: GNF-Pf4492; GNF-Pf-4492; TCMDC-124576

IUPAC/Chemical Name: 1-(4-(4-bromophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-(2,4-difluorophenyl)urea

InChi Key: YDMCNKUCKHWGIM-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H12BrF5N4O/c1-28-16(26-17(29)25-13-7-6-11(20)8-12(13)21)14(15(27-28)18(22,23)24)9-2-4-10(19)5-3-9/h2-8H,1H3,(H2,25,26,29)

SMILES Code: O=C(NC1=CC=C(F)C=C1F)NC2=C(C3=CC=C(Br)C=C3)C(C(F)(F)F)=NN2C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 475.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Flannery EL, McNamara CW, Kim SW, Kato TS, Li F, Teng CH, Gagaring K, Manary MJ, Barboa R, Meister S, Kuhen K, Vinetz JM, Chatterjee AK, Winzeler EA. Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials. ACS Chem Biol. 2015 Feb 20;10(2):413-20. doi: 10.1021/cb500616x. Epub 2014 Nov 5. PMID: 25322084; PMCID: PMC4340351.