WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130198
CAS#: N/A
Description: NSC-81355 is a Grp78 inhibitor.
Hodoodo Cat#: H130198
Name: NSC-81355
CAS#: N/A
Chemical Formula: C17H18N4O2S
Exact Mass: 342.12
Molecular Weight: 342.420
Elemental Analysis: C, 59.63; H, 5.30; N, 16.36; O, 9.34; S, 9.36
This product is not in stock, which may be available by custom synthesis.
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Synonym: NSC-81355; NSC81355; NSC 81355; Grp78 inhibitor 8
IUPAC/Chemical Name: (S)-N-(3-methyl-1-oxo-1-(thiazol-2-ylamino)butan-2-yl)-1H-indole-2-carboxamide
InChi Key: XOWYFNSUXHAORU-AWEZNQCLSA-N
InChi Code: InChI=1S/C17H18N4O2S/c1-10(2)14(16(23)21-17-18-7-8-24-17)20-15(22)13-9-11-5-3-4-6-12(11)19-13/h3-10,14,19H,1-2H3,(H,20,22)(H,18,21,23)/t14-/m0/s1
SMILES Code: O=C(C(N1)=CC2=C1C=CC=C2)N[C@@H](C(C)C)C(NC3=NC=CS3)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 342.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Ambrose AJ, Sivinski J, Zerio CJ, Zhu X, Godek J, Kumirov VK, Coma Brujas T, Torra Garcia J, Annadurai A, Schmidlin CJ, Werner A, Shi T, Zavareh RB, Lairson L, Zhang DD, Chapman E. Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78. J Med Chem. 2023 Jan 12;66(1):677-694. doi: 10.1021/acs.jmedchem.2c01631. Epub 2022 Dec 14. PMID: 36516003.