WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130191
CAS#: N/A
Description: OFH5503, which consists of a muscarinergic M3 receptor ligand linked to a dye, is used for measuring binding affinities using flow cytometry, and has shown promise as a vital tool for furthering research on muscarinergic receptors.
Hodoodo Cat#: H130191
Name: OFH5503
CAS#: N/A
Chemical Formula: C58H64ClF2N11O4
Exact Mass: 1,051.48
Molecular Weight: 1,052.670
Elemental Analysis: C, 66.18; H, 6.13; Cl, 3.37; F, 3.61; N, 14.64; O, 6.08
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Synonym: OFH5503; OFH 5503; OFH-5503
IUPAC/Chemical Name: 5-(1-(5-(4-(6-(4-((((3'-chloro-4',5-difluoro-[1,1'-biphenyl]-2-yl)carbamoyl)oxy)methyl)piperidin-1-yl)hexyl)-1H-1,2,3-triazol-1-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(6-(dimethylamino)-3-(dimethyliminio)-3,10-dihydroacridin-9-yl)benzoate
InChi Key: OYWFGKOWALKMBK-UHFFFAOYSA-N
InChi Code: InChI=1S/C58H64ClF2N11O4/c1-68(2)43-16-19-46-53(33-43)62-54-34-44(69(3)4)17-20-47(54)56(46)45-18-13-40(30-49(45)57(73)74)55-36-72(67-65-55)27-11-7-10-26-71-35-42(64-66-71)12-8-5-6-9-25-70-28-23-38(24-29-70)37-76-58(75)63-52-22-15-41(60)32-48(52)39-14-21-51(61)50(59)31-39/h13-22,30-36,38H,5-12,23-29,37H2,1-4H3,(H2,63,73,74,75)
SMILES Code: O=C([O-])C1=CC(C2=CN(CCCCCN3N=NC(CCCCCCN4CCC(COC(NC5=CC=C(F)C=C5C6=CC=C(F)C(Cl)=C6)=O)CC4)=C3)N=N2)=CC=C1C7=C(C=C/8)C(NC9=C7C=CC(N(C)C)=C9)=CC8=[N+](C)/C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,052.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Köckenberger J, Fischer O, Konopa A, Bergwinkl S, Mühlich S, Gmeiner P, Kutta RJ, Hübner H, Keller M, Heinrich MR. Synthesis, Characterization, and Application of Muscarinergic M3 Receptor Ligands Linked to Fluorescent Dyes. J Med Chem. 2022 Dec 22;65(24):16494-16509. doi: 10.1021/acs.jmedchem.2c01376. Epub 2022 Dec 9. PMID: 36484801.