WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122819
CAS#: 1644386-69-5
Description: PA21A092 is a PfATP4 inhibitor.
Hodoodo Cat#: H122819
Name: PA21A092
CAS#: 1644386-69-5
Chemical Formula: C23H23ClFN5O
Exact Mass: 439.16
Molecular Weight: 439.920
Elemental Analysis: C, 62.80; H, 5.27; Cl, 8.06; F, 4.32; N, 15.92; O, 3.64
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Synonym: PA21A092; PA-21A092; PA21A092
IUPAC/Chemical Name: N-(4-(4-chloro-2-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl)-2-(2-isopropyl-1H-benzo[d]imidazol-1-yl)acetamide
InChi Key: AXHVMTZWSKDPRR-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H23ClFN5O/c1-13(2)22-26-18-7-5-6-8-19(18)30(22)12-20(31)27-23-21(14(3)28-29(23)4)16-10-9-15(24)11-17(16)25/h5-11,13H,12H2,1-4H3,(H,27,31)
SMILES Code: O=C(NC1=C(C2=CC=C(Cl)C=C2F)C(C)=NN1C)CN3C4=CC=CC=C4N=C3C(C)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 439.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Tewari SG, Kwan B, Elahi R, Rajaram K, Reifman J, Prigge ST, Vaidya AB,
Wallqvist A. Metabolic adjustments of blood-stage Plasmodium falciparum in
response to sublethal pyrazoleamide exposure. Sci Rep. 2022 Jan 21;12(1):1167.
doi: 10.1038/s41598-022-04985-7. PMID: 35064153; PMCID: PMC8782945.
2: Mohring F, van Schalkwyk DA, Henrici RC, Blasco B, Leroy D, Sutherland CJ,
Moon RW. Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite
Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs.
mBio. 2022 Oct 26;13(5):e0117822. doi: 10.1128/mbio.01178-22. Epub 2022 Oct 3.
PMID: 36190127; PMCID: PMC9600963.
3: Tewari SG, Elahi R, Kwan B, Rajaram K, Bhatnagar S, Reifman J, Prigge ST,
Vaidya AB, Wallqvist A. Metabolic responses in blood-stage malaria parasites
associated with increased and decreased sensitivity to PfATP4 inhibitors. Malar
J. 2023 Feb 14;22(1):56. doi: 10.1186/s12936-023-04481-x. PMID: 36788578; PMCID:
PMC9930341.