PA21A092

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H122819

CAS#: 1644386-69-5

Description: PA21A092 is a PfATP4 inhibitor.


Chemical Structure

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PA21A092
CAS# 1644386-69-5

Theoretical Analysis

Hodoodo Cat#: H122819
Name: PA21A092
CAS#: 1644386-69-5
Chemical Formula: C23H23ClFN5O
Exact Mass: 439.16
Molecular Weight: 439.920
Elemental Analysis: C, 62.80; H, 5.27; Cl, 8.06; F, 4.32; N, 15.92; O, 3.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: PA21A092; PA-21A092; PA21A092

IUPAC/Chemical Name: N-(4-(4-chloro-2-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl)-2-(2-isopropyl-1H-benzo[d]imidazol-1-yl)acetamide

InChi Key: AXHVMTZWSKDPRR-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H23ClFN5O/c1-13(2)22-26-18-7-5-6-8-19(18)30(22)12-20(31)27-23-21(14(3)28-29(23)4)16-10-9-15(24)11-17(16)25/h5-11,13H,12H2,1-4H3,(H,27,31)

SMILES Code: O=C(NC1=C(C2=CC=C(Cl)C=C2F)C(C)=NN1C)CN3C4=CC=CC=C4N=C3C(C)C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 439.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tewari SG, Kwan B, Elahi R, Rajaram K, Reifman J, Prigge ST, Vaidya AB,
Wallqvist A. Metabolic adjustments of blood-stage Plasmodium falciparum in
response to sublethal pyrazoleamide exposure. Sci Rep. 2022 Jan 21;12(1):1167.
doi: 10.1038/s41598-022-04985-7. PMID: 35064153; PMCID: PMC8782945.

2: Mohring F, van Schalkwyk DA, Henrici RC, Blasco B, Leroy D, Sutherland CJ,
Moon RW. Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite
Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs.
mBio. 2022 Oct 26;13(5):e0117822. doi: 10.1128/mbio.01178-22. Epub 2022 Oct 3.
PMID: 36190127; PMCID: PMC9600963.

3: Tewari SG, Elahi R, Kwan B, Rajaram K, Bhatnagar S, Reifman J, Prigge ST,
Vaidya AB, Wallqvist A. Metabolic responses in blood-stage malaria parasites
associated with increased and decreased sensitivity to PfATP4 inhibitors. Malar
J. 2023 Feb 14;22(1):56. doi: 10.1186/s12936-023-04481-x. PMID: 36788578; PMCID:
PMC9930341.