WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130190
CAS#: N/A
Description: Phenothiazine 2a is an inhibitor of farnesyltransferase, showing promise for use in antitumor applications.
Hodoodo Cat#: H130190
Name: Phenothiazine 2a
CAS#: N/A
Chemical Formula: C27H22N2O3S
Exact Mass: 454.14
Molecular Weight: 454.540
Elemental Analysis: C, 71.35; H, 4.88; N, 6.16; O, 10.56; S, 7.05
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Synonym: Phenothiazine 2a
IUPAC/Chemical Name: ethyl (E)-3-(3-(10-methyl-10H-phenothiazin-3-yl)acryloyl)indolizine-1-carboxylate
InChi Key: DEBGEDXBSMFDAS-WYMLVPIESA-N
InChi Code: InChI=1S/C27H22N2O3S/c1-3-32-27(31)19-17-23(29-15-7-6-8-20(19)29)24(30)14-12-18-11-13-22-26(16-18)33-25-10-5-4-9-21(25)28(22)2/h4-17H,3H2,1-2H3/b14-12+
SMILES Code: O=C(C1=C2C=CC=CN2C(C(/C=C/C3=CC=C4N(C)C5=C(C=CC=C5)SC4=C3)=O)=C1)OCC
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 454.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Moise IM, Ghinet A, Belei D, Dubois J, Farce A, Bîcu E. New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3730-4. doi: 10.1016/j.bmcl.2016.05.074. Epub 2016 May 26. PMID: 27282741.