TPB3P

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130205

CAS#: N/A

Description: TPB3P is a potent G4 binder that exhibits strong stabilization, increased selectivity for G4 as compared to duplex DNAs, and also displays high cytotoxicity in MCF-7, LN229 and HeLa cancer cells.

Chemical Structure

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TPB3P
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H130205
Name: TPB3P
CAS#: N/A
Chemical Formula: C51H81N9
Exact Mass: 819.66
Molecular Weight: 820.270
Elemental Analysis: C, 74.68; H, 9.95; N, 15.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: TPB3P

IUPAC/Chemical Name: 1,3,5,-tris(4-(((3-((3-(dimethylamino)propyl)amino)propyl)amino)methyl)phenyl)benzene

InChi Key: YMKHCMBLAUZNLF-UHFFFAOYSA-N

InChi Code: InChI=1S/C51H81N9/c1-58(2)34-10-31-52-25-7-28-55-40-43-13-19-46(20-14-43)49-37-50(47-21-15-44(16-22-47)41-56-29-8-26-53-32-11-35-59(3)4)39-51(38-49)48-23-17-45(18-24-48)42-57-30-9-27-54-33-12-36-60(5)6/h13-24,37-39,52-57H,7-12,25-36,40-42H2,1-6H3

SMILES Code: CN(CCCNCCCNCC1=CC=C(C2=CC(C3=CC=C(CNCCCNCCCN(C)C)C=C3)=CC(C4=CC=C(CNCCCNCCCN(C)C)C=C4)=C2)C=C1)C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 820.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Pont I, Galiana-Roselló C, Sabater-Arcis M, Bargiela A, Frías JC, Albelda MT, González-García J, García-España E. Development of potent tripodal G-quadruplex DNA binders and their efficient delivery to cancer cells by aptamer functionalised liposomes. Org Biomol Chem. 2023 Feb 1;21(5):1000-1007. doi: 10.1039/d2ob01911f. PMID: 36541358.