WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130201
CAS#: 2803461-76-7
Description: YEATS Inhibitor 7 is an ENL YEATS domain inhibitor for combatting leukemia.
Hodoodo Cat#: H130201
Name: YEATS Inhibitor 7
CAS#: 2803461-76-7
Chemical Formula: C17H19N5O
Exact Mass: 309.16
Molecular Weight: 309.370
Elemental Analysis: C, 66.00; H, 6.19; N, 22.64; O, 5.17
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Synonym: YEATS Inhibitor 7
IUPAC/Chemical Name: N-(4-((dimethylamino)methyl)benzyl)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide
InChi Key: INYAZFZIPMYIQV-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H19N5O/c1-21(2)10-14-5-3-13(4-6-14)9-18-17(23)15-7-8-16-20-19-12-22(16)11-15/h3-8,11-12H,9-10H2,1-2H3,(H,18,23)
SMILES Code: O=C(C1=CN2C(C=C1)=NN=C2)NCC3=CC=C(CN(C)C)C=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 309.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Ma XR, Xu L, Xu S, Klein BJ, Wang H, Das S, Li K, Yang KS, Sohail S, Chapman A, Kutateladze TG, Shi X, Liu WR, Wen H. Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain. J Med Chem. 2021 Aug 12;64(15):10997-11013. doi: 10.1021/acs.jmedchem.1c00367. Epub 2021 Jul 19. PMID: 34279931; PMCID: PMC8486320.