WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130217
CAS#: N/A
Description: TED-646 is a Pan-TEAD·YAP1 covalent antagonist.
Hodoodo Cat#: H130217
Name: TED-646
CAS#: N/A
Chemical Formula: C17H14F3N3O
Exact Mass: 333.11
Molecular Weight: 333.310
Elemental Analysis: C, 61.26; H, 4.23; F, 17.10; N, 12.61; O, 4.80
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Synonym: TED-646; TED646; TED 646
IUPAC/Chemical Name: 5-methoxy-4-((3-(trifluoromethyl)phenyl)amino)isoindoline-2-carbonitrile
InChi Key: GCTSHJXOIFKTDC-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H14F3N3O/c1-24-15-6-5-11-8-23(10-21)9-14(11)16(15)22-13-4-2-3-12(7-13)17(18,19)20/h2-7,22H,8-9H2,1H3
SMILES Code: N#CN1CC2=C(C(NC3=CC=CC(C(F)(F)F)=C3)=C(OC)C=C2)C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 333.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Bum-Erdene K, Yeh IJ, Gonzalez-Gutierrez G, Ghozayel MK, Pollok K, Meroueh SO. Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists. J Med Chem. 2023 Jan 12;66(1):266-284. doi: 10.1021/acs.jmedchem.2c01189. Epub 2022 Dec 23. PMID: 36562717.