WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130219
CAS#: N/A
Description: aLPs-5g is a photoswitchable ligand targeting the vasopressin V2 receptor, allowing for a large degree of control over binding duration of the ligand to V2R. Furthermore, aLPs-5g shows promise as a key agent in the development of a treatment for autosomal dominant polycystic kidney disease (ADPKD).
Hodoodo Cat#: H130219
Name: aLPs-5g
CAS#: N/A
Chemical Formula: C26H21ClN4O
Exact Mass: 440.14
Molecular Weight: 440.930
Elemental Analysis: C, 70.82; H, 4.80; Cl, 8.04; N, 12.71; O, 3.63
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Synonym: aLPs-5g; aLPs 5g
IUPAC/Chemical Name: (E)-(5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(p-tolyldiazenyl)phenyl)methanone
InChi Key: ZVWYOGGBJPAVTG-ZQHSETAFSA-N
InChi Code: InChI=1S/C26H21ClN4O/c1-18-8-10-20(11-9-18)28-29-21-12-13-23(24(27)15-21)26(32)31-17-22-6-4-14-30(22)16-19-5-2-3-7-25(19)31/h2-15H,16-17H2,1H3/b29-28+
SMILES Code: O=C(N1CC2=CC=CN2CC3=CC=CC=C13)C4=CC=C(/N=N/C5=CC=C(C)C=C5)C=C4Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 440.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Gu X, Yuan H, Zhao W, Sun N, Yan W, Jiang C, He Y, Liu H, Cheng J, Guo D. Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V2 Receptor in In Vitro, Ex Vivo, and In Vivo Models of ADPKD. J Med Chem. 2023 Jan 26;66(2):1454-1466. doi: 10.1021/acs.jmedchem.2c01625. Epub 2022 Dec 23. PMID: 36563185.