WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130224
CAS#: N/A
Description: AM11095 is an inhibitor of NAAA with demonstrated potential as a cancer therapeutic agent.
Hodoodo Cat#: H130224
Name: AM11095
CAS#: N/A
Chemical Formula: C18H17FN2O2S
Exact Mass: 344.10
Molecular Weight: 344.404
Elemental Analysis: C, 62.77; H, 4.98; F, 5.52; N, 8.13; O, 9.29; S, 9.31
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Synonym: AM11095; AM 11095; AM-11095
IUPAC/Chemical Name: 5-(3-fluoro-4-methoxyphenyl)-2-(((1s,3s)-3-isothiocyanatocyclobutoxy)methyl)pyridine
InChi Key: GAVRQMDMBSIEDN-IYBDPMFKSA-N
InChi Code: InChI=1S/C18H17FN2O2S/c1-22-18-5-3-12(6-17(18)19)13-2-4-14(20-9-13)10-23-16-7-15(8-16)21-11-24/h2-6,9,15-16H,7-8,10H2,1H3/t15-,16+
SMILES Code: S=C=N[C@@H]1C[C@H](OCC2=NC=C(C3=CC=C(OC)C(F)=C3)C=C2)C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 344.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Benchama O, Malamas MS, Praveen K, Ethier EC, Williams MK, Makriyannis A, Avraham HK. Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA). Sci Rep. 2022 Dec 23;12(1):22255. doi: 10.1038/s41598-022-26564-6. PMID: 36564457; PMCID: PMC9789040.
2. Congiu M, Micheli L, Santoni M, Sagheddu C, Muntoni AL, Makriyannis A, Malamas MS, Ghelardini C, Di Cesare Mannelli L, Pistis M. N-Acylethanolamine Acid Amidase Inhibition Potentiates Morphine Analgesia and Delays the Development of Tolerance. Neurotherapeutics. 2021 Oct;18(4):2722-2736. doi: 10.1007/s13311-021-01116-4. Epub 2021 Sep 22. PMID: 34553321; PMCID: PMC8804012.
3. Sagheddu C, Scherma M, Congiu M, Fadda P, Carta G, Banni S, Wood JT, Makriyannis A, Malamas MS, Pistis M. Inhibition of N-acylethanolamine acid amidase reduces nicotine-induced dopamine activation and reward. Neuropharmacology. 2019 Jan;144:327-336. doi: 10.1016/j.neuropharm.2018.11.013. Epub 2018 Nov 12. PMID: 30439418.