WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130220
CAS#: N/A
Description: SHC014748M is a PI3Kδ inhibitor that was proposed as a potential treatment for non-Hodgkin lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma. In an in vivo study in mice, SHC014748M was found to be highly selective and led to significant reduction in lymphoma cell growth. Furthermore, SHC014748M has undergone phase 1 and 2 clinical trials.
Hodoodo Cat#: H130220
Name: SHC014748M
CAS#: N/A
Chemical Formula: C23H21ClN6O4S
Exact Mass: 512.10
Molecular Weight: 512.970
Elemental Analysis: C, 53.85; H, 4.13; Cl, 6.91; N, 16.38; O, 12.48; S, 6.25
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Synonym: SHC014748M; SHC 014748M
IUPAC/Chemical Name: (S)-4-amino-6-((1-(8-chloro-4-oxo-2-phenyl-1,4-dihydroquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile methanesulfonate
InChi Key: GUZPLFWFFSZBIA-YDALLXLXSA-N
InChi Code: InChI=1S/C22H17ClN6O.CH4O3S/c1-12(28-22-15(10-24)21(25)26-11-27-22)17-18(13-6-3-2-4-7-13)29-19-14(20(17)30)8-5-9-16(19)23;1-5(2,3)4/h2-9,11-12H,1H3,(H,29,30)(H3,25,26,27,28);1H3,(H,2,3,4)/t12-;/m0./s1
SMILES Code: N#CC1=C(N[C@H](C2=C(C3=CC=CC=C3)NC4=C(C=CC=C4Cl)C2=O)C)N=CN=C1N.OS(=O)(C)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 512.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. https://clinicaltrials.gov/ct2/show/results/NCT04431089
2. Fan L, Wang C, Zhao L, Wang Z, Zhang X, Liu X, Cao L, Xu W, Li J. SHC014748M, a novel selective inhi-bitor of PI3Kδ, demonstrates promising preclinical antitumor activity in B cell lymphomas and chronic lymphocytic leukemia. Neoplasia. 2020 Dec;22(12):714-724. doi: 10.1016/j.neo.2020.10.004. Epub 2020 Oct 23. PMID: 33142237; PMCID: PMC7586065.
3. Guo F, Liu B, Li X, Wang H, Zhu X, Su Y, He C, Zhu M, Ding J, Xu Y, Zhao X, Wang Y, Shan R, Zhu J, Xie J, Ge Q, Fan L, Ding Y, Xie Y, Zhang C, Li H, Wang H, Zhou H. Mass balance, metabolic disposition, and pharmacokinetics of a novel selective inhibitor of PI3Kδ [14C] SHC014748M in healthy Chinese subjects following oral administration. Cancer Chemother Pharmacol. 2023 Feb;91(2):143-156. doi: 10.1007/s00280-022-04493-5. Epub 2022 Dec 27. PMID: 36572783.