WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130242
CAS#: N/A
Description: CRBN(FLT3)-8 is an FLT3-ITD degrader, through the ubiquitin-proteasome system. CRBN(FLT3)-8 was found to more effectively prevent/reduce the proliferation of FLT3-ITD mutant AML cells as compared to gilteritinib.
Hodoodo Cat#: H130242
Name: CRBN(FLT3)-8
CAS#: N/A
Chemical Formula: C52H70N12O9
Exact Mass: 1,006.54
Molecular Weight: 1,007.210
Elemental Analysis: C, 62.01; H, 7.01; N, 16.69; O, 14.30
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Synonym: CRBN(FLT3)-8; CRBN(FLT3) 8
IUPAC/Chemical Name: 3-((4-(4-(4-((1-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoyl)piperidin-4-yl)methyl)piperazin-1-yl)piperidin-1-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide
InChi Key: OWJOKOMNEUQNLB-UHFFFAOYSA-N
InChi Code: InChI=1S/C52H70N12O9/c1-3-38-48(55-34-15-27-72-28-16-34)59-49(46(57-38)47(53)67)56-35-7-8-40(42(31-35)71-2)62-21-13-36(14-22-62)61-25-23-60(24-26-61)32-33-11-19-63(20-12-33)44(66)17-29-73-30-18-54-39-6-4-5-37-45(39)52(70)64(51(37)69)41-9-10-43(65)58-50(41)68/h4-8,31,33-34,36,41,54H,3,9-30,32H2,1-2H3,(H2,53,67)(H2,55,56,59)(H,58,65,68)
SMILES Code: O=C(C1=NC(CC)=C(NC2CCOCC2)N=C1NC3=CC=C(N4CCC(N5CCN(CC6CCN(C(CCOCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)=O)CC6)CC5)CC4)C(OC)=C3)N
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,007.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Ohoka N, Suzuki M, Uchida T, Tsuji G, Tsukumo Y, Yoshida M, Inoue T, Demizu Y, Ohki H, Naito M. Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein. ACS Med Chem Lett. 2022 Nov 4;13(12):1885-1891. doi: 10.1021/acsmedchemlett.2c00402. PMID: 36518702; PMCID: PMC9743425.