Moracin C
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H330095

CAS#: 69120-06-5

Description: Moracin C is a phenolic compound isolated from Artocarpus heterophyllus. Moracin C suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Moracin C has been proven to exhibit inhibitory activities against lipoxygenase enzymes, TNF-α and interleukin-1β secretion, and proprotein convertase subtilisin/kexin type 9 expression.


Chemical Structure

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Moracin C
CAS# 69120-06-5

Theoretical Analysis

Hodoodo Cat#: H330095
Name: Moracin C
CAS#: 69120-06-5
Chemical Formula: C19H18O4
Exact Mass: 310.1205
Molecular Weight: 310.349
Elemental Analysis: C, 73.53; H, 5.85; O, 20.62

Price and Availability

Size Price Availability Quantity
10.0mg USD 950.0 2 Weeks
25.0mg USD 1450.0 2 Weeks
50.0mg USD 2450.0 2 Weeks
100.0mg USD 3850.0 2 Weeks
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Synonym: Moracin C;

IUPAC/Chemical Name: 1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-buten-1-yl)-

InChi Key: ZTGHWUWBQNCCOH-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18O4/c1-11(2)3-6-15-16(21)7-13(8-17(15)22)18-9-12-4-5-14(20)10-19(12)23-18/h3-5,7-10,20-22H,6H2,1-2H3

SMILES Code: OC1=CC(C2=CC3=CC=C(O)C=C3O2)=CC(O)=C1C/C=C(C)\C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Instruction:

Preparing Stock Solutions

The following data is based on the product molecular weight 310.349 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Parise A, De Simone BC, Marino T, Toscano M, Russo N. Quantum Mechanical Predictions of the Antioxidant Capability of Moracin C Isomers. Front Chem. 2021 Apr 21;9:666647. doi: 10.3389/fchem.2021.666647. PMID: 33968905; PMCID: PMC8097241.

2: Masagalli JN, BasavanaGowda MK, Chae HS, Choi WJ. Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells. Molecules. 2021 Mar 2;26(5):1327. doi: 10.3390/molecules26051327. PMID: 33801308; PMCID: PMC7958322.

3: You BH, BasavanaGowda MK, Lee JU, Chin YW, Choi WJ, Choi YH. Correction: Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Feb 5. doi: 10.1055/a-1384-8484. Epub ahead of print. Erratum for: Planta Med. 2021 Jan 26;: PMID: 33545721.

4: You BH, BasavanaGowda MK, Lee JU, Chin YW, Choi WJ, Choi YH. Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Jul;87(8):642-651. doi: 10.1055/a-1321-1519. Epub 2021 Jan 26. Erratum in: Planta Med. 2021 Feb 05;: PMID: 33498088.

5: Li X, Xie H, Zhan R, Chen D. Effect of Double Bond Position on 2-Phenyl- benzofuran Antioxidants: A Comparative Study of Moracin C and Iso-Moracin C. Molecules. 2018 Mar 24;23(4):754. doi: 10.3390/molecules23040754. PMID: 29587376; PMCID: PMC6017532.

6: Yao X, Wu D, Dong N, Ouyang P, Pu J, Hu Q, Wang J, Lu W, Huang J. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci. 2016 Jul 25;17(8):1199. doi: 10.3390/ijms17081199. PMID: 27463712; PMCID: PMC5000597.

7: Kim YJ, Sohn MJ, Kim WG. Chalcomoracin and moracin C, new inhibitors of Staphylococcus aureus enoyl-acyl carrier protein reductase from Morus alba. Biol Pharm Bull. 2012;35(5):791-5. doi: 10.1248/bpb.35.791. PMID: 22687419.