WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130251
CAS#: 2489404-97-7
Description: Osunprotafib, also known as ABBV-CLS-484 and AC-484, an inhibitor of PTPN2/N1, has shown promise as an anti-tumor agent. ABBV-CLS-484 increases cytotoxic T-cell activity and the susceptibility of tumor cells to the immune system. Phase 1 clinical trials are currently being undergone for ABBV-CLS-484, both as a monotherapy, and in combination with a PD-1 targeting agent for the treatment of relapsed or advanced HNSCC.
Hodoodo Cat#: H130251
Name: Osunprotafib
CAS#: 2489404-97-7
Chemical Formula: C17H24FN3O4S
Exact Mass: 385.15
Molecular Weight: 385.450
Elemental Analysis: C, 52.97; H, 6.28; F, 4.93; N, 10.90; O, 16.60; S, 8.32
Synonym: ABBV-CLS-484; Abbv-CLS484; ABBV-CLS 484; CLS-484; CLS 484, AC-484; AC 484; AC484; osunprotafib;
IUPAC/Chemical Name: (R)-5-(1-fluoro-3-hydroxy-7-(isopentylamino)-5,6,7,8-tetrahydronaphthalen-2-yl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide
InChi Key: DVFCRTGTEXUFIN-GFCCVEGCSA-N
InChi Code: InChI=1S/C17H24FN3O4S/c1-10(2)5-6-19-12-4-3-11-7-14(22)17(16(18)13(11)8-12)21-9-15(23)20-26(21,24)25/h7,10,12,19,22H,3-6,8-9H2,1-2H3,(H,20,23)/t12-/m1/s1
SMILES Code: O=C(CN1C2=C(O)C=C3CC[C@@H](NCCC(C)C)CC3=C2F)NS1(=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 385.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. https://aacrjournals.org/cancerres/article/82/12_Supplement/ND06/703170/Abstract-ND06-ABBV-CLS-484-An-active-site-PTPN2-N1
2. https://clinicaltrials.gov/ct2/show/study/NCT04777994