WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130258
CAS#: N/A
Description: GD433 is a NTMT1 chemical probe for in vivo use.
Hodoodo Cat#: H130258
Name: GD433
CAS#: N/A
Chemical Formula: C20H24FN3O3S
Exact Mass: 405.15
Molecular Weight: 405.488
Elemental Analysis: C, 59.24; H, 5.97; F, 4.69; N, 10.36; O, 11.84; S, 7.91
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Synonym: GD433; GD 433; GD-433
IUPAC/Chemical Name: (S)-quinuclidin-3-yl (2-(2-(4-fluoro-3-hydroxyphenyl)thiazol-4-yl)propan-2-yl)carbamate
InChi Key: LRJXHGILPIXDQG-MRXNPFEDSA-N
InChi Code: InChI=1S/C20H24FN3O3S/c1-20(2,23-19(26)27-16-10-24-7-5-12(16)6-8-24)17-11-28-18(22-17)13-3-4-14(21)15(25)9-13/h3-4,9,11-12,16,25H,5-8,10H2,1-2H3,(H,23,26)/t16-/m1/s1
SMILES Code: O=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C(O)=C4)=N3)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 405.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Deng Y, Dong G, Meng Y, Noinaj N, Huang R. Structure-Activity Relationship Studies of Venglustat on NTMT1 Inhibition. J Med Chem. 2023 Jan 26;66(2):1601-1615. doi: 10.1021/acs.jmedchem.2c01854. Epub 2023 Jan 12. PMID: 36634151; PMCID: PMC9892271.